By A. G. Fishburn
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Extra resources for An Introduction to Pharmaceutical Formulation
1963, 52, 917 aqueous solvents in parenteral products). (Non- CHAPTER 3 THICKENERS AND BINDERS; FATS AND WAXES Thickeners and Binders For various reasons, it may be necessary to increase the viscosity of a formulation and a wide range of materials are available for this purpose. The choice is dependent partly on the reason for thickening and partly on the route of administration ; occasionally, one must take into account also the possibility of incompatibility with the drugs and/or other excipients.
P. I t is a good emulsifier for other oils a n d fats b u t has the limitation of soap in that it is incompatible with large cations and is not suitable for administration by mouth. A dilute a n d thin emulsion, which might otherwise tend to crack, can often b e stabilized by about 1 per cent of Self-emulsifying Monostearin. G. This is a polyethylene glycol of high molecular weight (31003700) which, in appearance, is a creamy-white, odourless, waxy solid. C. P. I n spite of its waxy appearance, it is strongly hydrophilic a n d is soluble in water (about 30 per cent) a n d in alcohol (about 50 per cent).
68"). (ii) The esters (and ether jesters) Long carbon chains, in the form of fatty acids, may be linked to polyhydric alcohols by esterification. If the hydrophilic component provided by the latter is sufficiently large, a suitable balance is established. OH Since this has only a small hydrophilic component, it is mixed with about 5 per cent of soap to restore the balance. Self-emulsifying monostearin is used in concentrations of 5-20 per cent for the preparation of creams but is not administered internally.
An Introduction to Pharmaceutical Formulation by A. G. Fishburn