By Thomas Jue, Kazumi Masuda
In line with the fashion of the instruction manual of contemporary Biophysics, this fourth quantity, program of Near-Infrared Spectroscopy in Biomedicine, balances the necessity for actual science/mathematics formalism with a requirement for biomedical views. every one bankruptcy divides the presentation into significant elements: the 1st establishes the conceptual framework and describes the instrumentation or approach, whereas the second one illustrates present functions in addressing complicated biology questions. With the extra sections on additional analyzing, difficulties, and references, the reader can discover a few bankruptcy rules extra broadly.
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Yamashita Fig. 12 Effect of fat thickness on the relationship between the slope of light intensity and the absorption coefficient of muscle apparatus and NIRS instrument. Since the effects of micrometer inhomogeneity are reflected in the value of the scattering coefficient, estimation of the optical properties of each layer will be important for accurate oxygenation measurement. 1 A random number used on Monte Carlo simulation should be long period and of almost uniform distribution. How can this random number be generated?
However, the region of brain activation is often smaller than the volume of tissue interrogated; hence, the detected light travels through the activated region that contributes to the NIRS signal which is shorter than the partial optical pathlength in the brain. 3 E. Okada Spatial Sensitivity Profile A more rigorous parameter than partial optical pathlength is necessary to represent the spatial distribution of tissue volume that contributes to the NIRS signal. The volume of tissue in which absorption change contributes to a change in optical density can be described by a spatial sensitivity profile.
The distribution of brain activation in the cortex is projected onto a two-dimensional plane on the brain surface [49, 50]. NIRS topography has the advantage of short image acquisition time compared to NIRS tomography because the typical probe spacing for the NIRS topography is about 30 mm. In addition, the forward problem is not essential for NIRS topography because the image can be generated by the mapping method without solving the inverse problem. Based on these advantages, NIRS topography has been extensively applied to brain-function imaging for 3 Photon Migration in NIRS Brain Imaging 41 Fig.
Application of Near Infrared Spectroscopy in Biomedicine by Thomas Jue, Kazumi Masuda