By Alfred N. Fonteh (auth.), Alfred N. Fonteh, Robert L. Wykle (eds.)
Arachidonic acid (AA) and different 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of irritation referred to as eicosanoids. those mediators are serious in ailment approaches and in regulating general phone functionality. home improvement is critical in protecting homeostasis and in regulating phone functionality through dictating how PUFAs are switched over to lipid mediators of irritation. therefore, PUFA home improvement is a serious procedure within the biosynthesis of a mess of mediators, and knowing this procedure will get to the bottom of greater healing goals for controlling inflammatory ailments equivalent to bronchial asthma and Alzheimer’s disease.
AA metabolism is defined in an built-in context linking the reworking procedures with the biosynthesis of mediators and ailments. by way of following the move of the substrate (AA), the quantity describes how upstream biosynthetic pathways impression the formation of lipid mediators of irritation, displaying the metabolic interrelationship among all AA-derived mediators.
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Additional info for Arachidonate Remodeling and Inflammation
Our studies also show that sPLA/s cause the selective release of AA and not other more abundant fatty acids from cells that express sPLA 2 receptors . In contrast, cells that do not express sPLA 2 receptors do not selectively release AA when incubated with low amounts of sPLA 2 • Recently, different subtypes of membrane receptors for sPLA2 have been identified in a variety of cells by determining their affinities for various types of sPLA2 • Arita and colleagues described the existence of a specific receptor family termed PLATI receptor that is abundant in brain and several other tissues and has high affinity for the binding of pancreatic-type PLA2 [133-136].
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Biochemistry 32: 573-582 37 Mounier C, Vargaftig BB, Franken PA, Verheij HM, Bon C, Touqui L (1994) Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2. Biochim Biophys Acta 1214: 88-96 28 Phospholipase A2 and remodeling in inflammatory cells 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Baker SF, Othman R, Wilton DC (1998) Tryptophan-containing mutant of human (group IIa) secreted phospholipase A2 has a dramatically increased ability to hydrolyze phosphatidylcholine vesicles and cell membranes.
Arachidonate Remodeling and Inflammation by Alfred N. Fonteh (auth.), Alfred N. Fonteh, Robert L. Wykle (eds.)